Founders Publications - Luke O'Neill
Luke O誰eill
Fitzgerald, K.A., Palsson-McDermott, E.M., Bowie, A.G., Jeffries, C.A., Mansell, A., Brady, G., Brint, E., Dunne, A., Gray, P., Harte, M., McMurray, D., Smith, D.E., Sims, J.E., Bird, T.A. and O誰eill, L.A.J. (2001) Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413, 78-83
Harte, MT, Haga, I, Maloney, G, Gray, P, Reading, PC, Bartlett, N, Smith, GL, Bowie, AG* and O誰eill, LAJ* (2003) The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defence. J. Exp. Med. 197(3):343-351 *Joint senior authorship
Jefferies CA, Doyle S, Brunner C, Dunne A, Brint E, Wietek C, Walch E, Wirth T, O誰eill LA. (2003) Bruton痴 tyrosine kinase is a TIR domain binding protein that participates in NFkappa B activation by Toll-like receptor 4. J Biol Chem. 278(28):26258-64
O誰eill, LAJ (2003) The Toll/IL-1 receptor adapter family grows to 5 members. Trends in Immunol 24(6):286-90
Wietek, C, Miggin SM, Jefferies CA and O誰eill LAJ (2003) IRF-3- mediated activation of the interferon- sensitive response element by TLR4 but not TLR3 requires the p65 subunit of NF-kappaB. J Biol Chem. 278,50923-50931
O誰eill LA (2004) After the Toll rush. Science 303, 1481-1482
Brint, E, Xu, D, Liu, H, Dunne, A, McKenzie, A, O誰eill, LAJ* and Liew FY* (2004) T1/ST2 is an inhibitor of IL-1R and TLR4 signalling and maintains endotoxin tolerance. Nature Immunol. 5, 373-379 *Joint senior authorship
O誰eill LAJ (2004) TLRs: Professor Mechnikov, sit on your hat.Trends in Immunol. 25, 687-693
O誰eill LA (2005) Immunity痴 early warning system. Scientific American, January 2005, 32-40
O誰eill LA (2005) TLRs play good cop, bad cop in the lung. Nat Med. 2005 Nov;11(11):1161-2
Brady GA, Boggan, L, Bowie, AG and O誰eill LA (2005) Schlafen-1 causes a cell cycle arrest by inhibiting induction of Cyclin D1. J Biol Chem 280(35):30723-34
Liew, E, Xu, D, Brint, E, O誰eill, LA (2005) Negative regulation of TLR signalling. Nature Rev. Immunol. Jun;5(6):446-58
Doyle S, Jefferies CA and O誰eill LA (2005) Bruton痴 tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NF-kappa B activation by LPS. J Biol Chem. 280(25):23496-501
Mansell, A, Simth, R, Doyle S, Gray P, Fennen JE, Crack P, Nicholson S, Hilton DJ, O誰eill LA* and Hertzog P* (2006) Suppressor of cytokine signaling (SOCS)-1 negatively regulates Toll-like receptor signaling by targeting Mal for degradation. Nature Immunol. 7(2):148-55. Epub 2006 Jan 15. *Joint senior authorship
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